Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir
نویسندگان
چکیده
منابع مشابه
Influenza virus susceptibility and resistance to oseltamivir.
Oseltamivir phosphate is a prodrug of oseltamivir carboxylate, a highly specific inhibitor of influenza virus neuraminidases. Given that oseltamivir carboxylate binds to highly conserved, essential amino acids in the catalytic site of the enzyme, and that the activity of neuraminidase is critical for virus release from infected cells and subsequent virus spread, the drug was expected to have a ...
متن کاملEmergence of intratreatment resistance to oseltamivir in pandemic influenza A H1N1 2009 virus.
BACKGROUND Pandemic influenza A H1N1 2009 virus presents a new challenge to health authorities and communities worldwide. In Argentina, the outbreak was at its peak by the end of June 2009, during the southern winter. A systematic analysis of samples from patients with pandemic H1N1 2009 studied in our laboratory (Virology Laboratory, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina) dete...
متن کاملRapid Emergence of Oseltamivir Resistance
1. Shimada T, Gu Y, Kamiya H, Komiya N, Odaira F, Sunagawa T, et al. Epidemiology of infl uenza A (H1N1)v virus infection in Japan, May–June 2009. Euro Surveill. 2009;14:pii:19244. 2. Likos AM, Kelvin DJ, Cameron CM, Rowe T, Kuehnert MJ, Norris PJ. Infl uenza viremia and the potential for blood-borne transmission. Transfusion. 2007;47:1080–8. DOI: 10.1111/j.15372995.2007.01264.x 3. Khakpour M, ...
متن کاملEmergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe.
The latest Healthcare Associated Infections quarterly report was published on 30 January. This includes new quarterly data for both MRSA bacteraemia and C. difficile infection, and six-monthly data for MRSA bacteraemia, collected through the mandatory surveillance systems. These data are available, together with commentaries and historical annual data, at In the six-month period April – Septemb...
متن کاملGenetically determined, interferon-dependent resistance to influenza virus in mice
The genetically determined resistance towards orthomyxoviruses exhibited by mice homozygous (A2G) or heterozygous (A2G X A/J) for the gene Mx was abolished or greatly diminished by treatment with anti-interferon globulin (AIF). AIF induced increased susceptibility to challenge with hepatotropic, neurotropic, and pneumotropic strains of influenza A virus. Hepatotropic virus titers in blood and l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microorganisms
سال: 2021
ISSN: 2076-2607
DOI: 10.3390/microorganisms9061196